????? : ???? ????? ?????? ???????? ?? ??? ?????? ??????? ??????. ???? ?????? ???????? ?? ???? ??????? ??? ???? ???????? ??????? ???? ?? ????? ??????????? ????????? ?????? ??? ????? ???? ????????: ????? ???????Misoprostol, when administered to breeding male and female rats at doses 6.25 times to 625 times the maximum advisable human therapeutic dose